ABSTRACT
Tailgut cysts are rare congenital lesions presenting as retrorectal space masses. They can occur in all age groups. Patients often present with ill-defined nonspecific symptoms and the diagnosis if often delayed. Malignancy arising in a tailgut cyst is an even rarer and unique occurrence. A precise diagnosis can be made only after complete excision and histopathological examination of the retrorectal space mass. We describe here a case of a 63-year-old male presenting with chronic constipation, who was diagnosed with a well-differentiated neuroendocrine tumor (Grade I) arising in a tailgut cyst after surgical excision.
Subject(s)
Female , Histocytochemistry , Humans , Lymph Nodes/pathology , Mesentery/pathology , Microscopy , Middle AgedABSTRACT
We report a female neonate, who presented with abdominal distension and failure to pass meconium. Antenatal ultrasound at 32 weeks gestation and postnatal ultrasound on day1 suggested intestinal obstruction. During laparatomy, atresia of distal jejunum was found. The lumen of the distal segment contained an intussusceptum. Resection of the blind ends was done and end-to-end anastomosis was performed.
Subject(s)
Antigens, CD34/analysis , S100 Calcium Binding Protein G/analysis , Histocytochemistry , Humans , Immunohistochemistry , Keratins/analysis , Male , Mesothelioma/diagnosis , Mesothelioma/pathology , Microscopy , Middle Aged , Mucin-1/analysis , Testicular Neoplasms/diagnosis , Testicular Neoplasms/pathologyABSTRACT
Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.
Subject(s)
Blindness/etiology , Blindness/surgery , Eye Enucleation , Female , Glial Fibrillary Acidic Protein/metabolism , Gliosis/complications , Gliosis/diagnosis , Gliosis/metabolism , Gliosis/physiopathology , Humans , Immunohistochemistry , Middle Aged , Phosphopyruvate Hydratase/metabolism , Retinal Diseases/complications , Retinal Diseases/diagnosis , Retinal Diseases/metabolism , Retinal Diseases/physiopathology , S100 Proteins/metabolism , Severity of Illness Index , Tomography, X-Ray Computed , Vision, MonocularABSTRACT
This report describes a case report of a postmortem performed on a 5-year old patient of Tay-Sachs disease, presenting with failure to thrive, muscular flaccidity, and cherry-red spots on macula on fundoscopy. There was no history of similarly affected sibling or any other family member. The diagnosis was confirmed by enzyme studies. At postmortem, there was no organomegaly. The brain, on microscopy, showed vacuolated swollen neurons.
Subject(s)
Autopsy , Brain/pathology , Child, Preschool , Diagnosis, Differential , Humans , India , Male , Tay-Sachs Disease/diagnosisABSTRACT
Pneumocystis carinii pneumonia (PCP) has been reported as one of the opportunistic pathogens in AIDS. The significance of this pathogen in AIDS is well established so that, the diagnosis of PCP in an adult simultaneously establishes the diagnosis of AIDS. This point is well emphasised in the CDC case definition of AIDS. In western literature, the occurrence of PCP in AIDS is widely reported. However, in Indian literature only sporadic case reports have been documented. This study reports 5 cases of PCP encountered amongst 34 AIDS-autopsies studied. PCP alone was present in 2 cases. It is worth noting that it was simultaneously associated with cryptococcosis, tuberculosis and CMV in 3 remaining cases, highlighting the need for extensive investigations even after establishing the diagnosis of PCP in a known full blown AIDS patient.
Subject(s)
AIDS-Related Opportunistic Infections/pathology , Adult , Cryptococcosis/complications , Cytomegalovirus Infections/complications , Humans , India , Male , Middle Aged , Pneumonia, Pneumocystis/complications , Tuberculosis, Pulmonary/complicationsABSTRACT
A case report of a squamous cell carcinoma arising in a dermoid cyst of the ovary in a 29 year old patient is presented. Such an occurrence in young patients is unusual.